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Updated: Jan 9, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
[68Ga]Ga-FAPI Versus [18F]FDG PET/CT in Signet Ring Cell Carcinoma with Linitis Plastica: Diagnostic Performance and
Roopal Agrawal1, Keerti Sitani1, Sandip Basu2
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Mumbai, India; and Homi Bhabha National Institute, Mumbai, India.
Abstract:
The diagnosis and staging of primary gastric carcinoma, particularly linitis plastica morphology, is challenging. Fibroblast activation protein, abundantly expressed in cancer-associated fibroblasts and absent in normal gastrointestinal mucosa, enables high tumor-to-background contrast. We report 2 cases of signet ring cell gastric adenocarcinoma with linitis plastica morphology, demonstrating minimal uptake on [18F]FDG PET/CT but intense uptake on [68Ga]Ga-FAPI-04 PET/CT. These findings highlight the superior diagnostic performance of fibroblast activation protein inhibitor imaging in this challenging subset of gastric cancers.
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