Discordance of Dual-Tracer PET/CT with Histopathology in a Grade I Pancreatic Neuroendocrine Tumor: A Diagnostic Conundrum
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Updated: May 5, 2026
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Sarina Shah1,2, Keerti Sitani1,2, Gauri Deshpande2,3
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, Maharashtra, India.
Objectives:
Neuro endocrine tumors (NETs) demonstrate complex biology where imaging and histology can at times show discordance in a real-world scenario.
Materials And Methods:
We herein present a patient of grade I pancreatic NET showing atypical low somatostatin receptor expression on 68 Ga-DOTATATE PET/CT (positron emission tomography/computed tomography) but intense fluorine-18-deoxyglucose ( 18 FDG) avidity, and when interpreted together, these findings showed discordance with histopathology.
Results:
The case highlights the crucial role of dual-tracer PET/CT in navigating the tumor biology and landscape of NET and the need for novel strategies to complement traditional histopathology that would enable better therapeutic decision-making.
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