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Updated: Jan 9, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
No evidence for genetic role of the tumor necrosis factor pathway in Parkinson's disease
Morvarid Ghamgosar Shahkhali1,2, Lang Liu1,2,3, Emma N Somerville1,2
1The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Abstract:
Tumor necrosis factor (TNF) inhibition is under investigation as a therapeutic strategy for Parkinson's disease (PD) and REM sleep behavior disorder (RBD), yet supporting genetic evidence is limited. We used Summary-data-based Mendelian Randomization (SMR) to test whether expression level of ten TNF-related genes were causally linked to PD risk, PD progression, or RBD risk. We also analyzed associations between common and rare variants in these genes, and performed pathway specific polygenic risk score analysis, with PD. Overall, our findings do not support a genetic link between the TNF signaling and PD or RBD, arguing against this pathway as a genetically validated therapeutic target.
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