Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

12.1K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
12.1K
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

14.7K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
14.7K
Cryo-electron Microscopy01:28

Cryo-electron Microscopy

4.1K
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-lived multilevel coherences and spin-1 dynamics encoded in the rotational states of ultracold molecules.

Nature communications·2025
Same author

Long-lived entanglement of molecules in magic-wavelength optical tweezers.

Nature·2025
Same author

A motorized rotation mount for the switching of an optical beam path in under 20 ms using polarization control.

The Review of scientific instruments·2023
Same author

Sticky collisions of ultracold RbCs molecules.

Nature communications·2019
Same journal

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice.

Nature communications·2026
Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026
Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026
Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026
Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026
Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.7K

Multi-state detection and spatial addressing in a microscope for ultracold molecules.

Jonathan M Mortlock1, Adarsh P Raghuram2, Benjamin P Maddox2

  • 1Department of Physics, Durham University, South Road, Durham, DH1 3LE, United Kingdom. jonathan.m.mortlock@durham.ac.uk.

Nature Communications
|December 9, 2025
PubMed
Summary
This summary is machine-generated.

We developed a new method to detect individual ultracold molecules and their states in real-time. This technique allows precise measurements of molecular properties, crucial for quantum gas microscopy and advanced molecular physics experiments.

More Related Videos

Picometer-Precision Atomic Position Tracking through Electron Microscopy
15:04

Picometer-Precision Atomic Position Tracking through Electron Microscopy

Published on: July 3, 2021

8.2K
Conducting Multiple Imaging Modes with One Fluorescence Microscope
08:32

Conducting Multiple Imaging Modes with One Fluorescence Microscope

Published on: October 28, 2018

10.2K

Related Experiment Videos

Last Updated: Jan 9, 2026

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.7K
Picometer-Precision Atomic Position Tracking through Electron Microscopy
15:04

Picometer-Precision Atomic Position Tracking through Electron Microscopy

Published on: July 3, 2021

8.2K
Conducting Multiple Imaging Modes with One Fluorescence Microscope
08:32

Conducting Multiple Imaging Modes with One Fluorescence Microscope

Published on: October 28, 2018

10.2K

Area of Science:

  • Quantum physics
  • Ultracold atoms and molecules
  • Quantum gas microscopy

Background:

  • Precise measurement of ultracold molecules is essential for quantum gas experiments.
  • Current methods lack the resolution for individual molecule detection in bulk samples.

Purpose of the Study:

  • To demonstrate in-situ detection of individual ultracold molecules.
  • To enable precise measurements of molecular properties like density and internal states.

Main Methods:

  • Utilizing techniques from atomic quantum gas microscopy.
  • Pinning molecules in a 2D optical lattice and dissociating them.
  • Collecting fluorescence from constituent atoms with a high-NA objective.

Main Results:

  • Achieved single-molecule detection resolution down to sub-micron lattice spacing.
  • Enabled precise measurement of density-dependent collisional losses.
  • Demonstrated simultaneous detection of molecular position and rotational state.

Conclusions:

  • The developed method provides unprecedented access to individual ultracold molecule properties.
  • This technique is vital for advancing research in ultracold molecular gases and quantum simulations.