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Updated: Jan 9, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Bioactive Glass for Bone Tissue Regeneration: Focusing on the Key Biological Properties.

Shital S Shendage1,2, Gokul Kamble1, Rutuja Chavan1

  • 1Green Nanotechnology Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India.

ACS Biomaterials Science & Engineering
|December 10, 2025
PubMed
Summary

Bioactive glass (BG) actively promotes bone healing through biological mechanisms like osteoconduction and angiogenesis. This review focuses on BG

Keywords:
artificial bonebioactive glassbiological propertiesbonebone tissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Engineering

Background:

  • Human bone regeneration faces challenges in artificial material development.
  • Existing literature often emphasizes structural aspects of bioactive glass (BG).
  • A focus on BG's biological properties for tissue regeneration is needed.

Purpose of the Study:

  • To review the biological mechanisms of bioactive glass (BG) in bone regeneration.
  • To highlight BG's influence on cellular behavior and the healing microenvironment.
  • To provide a framework for understanding BG's regenerative potential.

Main Methods:

  • Critical examination of key biological mechanisms: osteoconduction, osteoinduction, angiogenesis, antibacterial activity, and immunomodulation.
  • Review of recent in vitro and in vivo findings.
  • Comparison of biological efficacy across different BG compositions.

Main Results:

  • BG actively influences cellular behavior and the healing microenvironment.
  • Specific biological mechanisms drive tissue regeneration.
  • Different BG compositions exhibit varying biological efficacy.

Conclusions:

  • Bioactive glass (BG) shows significant potential in bone tissue engineering due to its biological properties.
  • Further research is needed to address challenges in ion release, mechanical properties, degradation, and clinical translation.
  • Optimizing BG's biological interface is key to enhancing its therapeutic performance.