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Progressive Retinal Toxicity Nine Years After Hydroxychloroquine Discontinuation: A Case Report
Christina Karakosta1, Susan M Downes2,3
1Ophthalmology, Oxford University Hospitals NHS Foundation Trust, Oxford, GBR.
Cureus
|December 10, 2025
Summary
Hydroxychloroquine (HCQ) retinopathy can worsen for years after stopping the drug. Early detection of HCQ retinal toxicity is crucial for managing irreversible vision damage.
Area of Science:
- Ophthalmology
- Rheumatology
- Toxicology
Background:
- Hydroxychloroquine (HCQ) is commonly prescribed for autoimmune conditions like rheumatoid arthritis.
- Long-term HCQ use can lead to retinal toxicity, a potentially irreversible condition.
- Monitoring for HCQ retinopathy is essential, but progression patterns after drug cessation are not fully understood.

