Glucose detection using a tilted fiber Bragg grating coated with a GO-PBA composite layer

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Materials Science

Background:

• Diabetes mellitus requires continuous blood glucose monitoring for effective management.
• Existing glucose sensors face challenges in sensitivity, measurement range, and selectivity.
• Development of advanced biosensors is crucial for improving diabetes care.

Purpose of the Study:

• To propose and experimentally validate a novel glucose sensor.
• To achieve a low limit of detection (LOD) and a broad measurement range.
• To ensure high selectivity and practical applicability for serum glucose monitoring.

Main Methods:

• Fabrication of a sensor using a tilted fiber Bragg grating coated with graphene oxide (GO).
• Immobilization of pyrene-1-boric acid on the GO layer as a bio-recognition element for glucose.
• Experimental validation of LOD, linear response range, selectivity against other sugars, and performance in real serum samples.

Main Results:

• The sensor achieved a low LOD of 10 nM.
• A linear response was observed from 10 nM to 10 μM, with functionality up to 20 mM.
• The sensor demonstrated high selectivity, with responses 2-3 times stronger than fructose and 3-5 times stronger than galactose.
• Practical applicability was confirmed through comparable performance to standard solutions in serum samples.

Conclusions:

• The proposed glucose sensor offers high sensitivity and a broad measurement range.
• Its compact size, ease of fabrication, and selectivity make it promising for biomedical and biochemical applications.
• This technology holds potential for improved diabetes mellitus management and continuous glucose monitoring.