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Updated: Jan 9, 2026

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Adult-Onset Epstein-Barr Virus-Associated T-Cell Lymphoproliferative Disease with Central Nervous System Involvement

Atsushi Wada1, Hiro Tatetsu1, Shinya Endo1

  • 1Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan.

Blood Cell Therapy
|December 10, 2025
PubMed
Summary

Adults with Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disease (EBV+ T-cell LPD) can develop central nervous system (CNS) involvement. This case shows successful treatment of CNS relapse using haploidentical stem cell transplantation with post-transplant cyclophosphamide.

Keywords:
EBV-associated T-cell LPDcentral nervous systemhaploidentical stem cell transplantationpost-transplant cyclophosphamide (PTCy)

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