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Effects of Angelica archangelica Extract on Overactive Bladder: A Pilot Randomized Controlled Trial
Jaime López-Seoane1,2, Eva Gesteiro1,2, María José Castro-Alija3
1ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF Universidad Politécnica de Madrid Madrid Spain.
Food Science & Nutrition
|December 10, 2025
Summary
Angelica archangelica (AA) leaf extract supplementation significantly reduced daytime voids and improved quality of life in adults with overactive bladder (OAB) syndrome over six weeks. This natural approach also showed positive effects on nocturia and storage symptoms.
Area of Science:
- Urology
- Pharmacology
- Natural Product Research
Background:
- Overactive bladder (OAB) affects 10.8-12.8% of European adults, significantly impacting quality of life (QoL).
- Conventional OAB treatments, such as antimuscarinic drugs, often have low adherence due to limited efficacy and side effects.
- There is a need for alternative, well-tolerated treatments for OAB symptoms.
Purpose of the Study:
- To investigate the efficacy of natural supplementation with Angelica archangelica (AA) leaf extract in managing OAB symptoms.
- To evaluate the impact of AA supplementation on daytime voids, nocturia, urgency, and overall quality of life.
- To compare the effects of AA supplementation against a placebo in a randomized, triple-blind, controlled trial.
Main Methods:
- A 6-week randomized, triple-blind, controlled pilot study (NCT04357223) involving 143 adults (18-75 years) with OAB symptoms.
- Participants were assigned to receive either AA leaf extract (SUP) or placebo (PLA) in a 1.75:1 ratio.
- OAB symptomatology was assessed using a 3-day voiding diary (3-dVD) and the International Prostate Symptom Score (IPSS), including total and storage subscores.
Main Results:
- Angelica archangelica (AA) supplementation led to significant improvements in daytime voids (p=0.004) and the IPSS storage subscore (p=0.025) compared to placebo.
- A significant improvement in QoL was observed in the AA group (p<0.001).
- A nearly significant improvement in nocturia was noted (p=0.069), with clinically meaningful reductions in the IPSS total score for the AA group.
Conclusions:
- Six weeks of Angelica archangelica (AA) leaf extract supplementation effectively reduced daytime voids and improved the IPSS storage subscore in adults with OAB syndrome.
- AA supplementation significantly enhanced the quality of life for individuals experiencing OAB symptoms.
- The findings suggest that AA leaf extract is a promising natural alternative for managing OAB, with potential benefits for nocturia.
