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Bidirectional Relationship Between Myopia and Mental Disorders
Dan-Lin Li1, Su-Tong Yu2, Li-Jun Zhang3
1School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Depression and Anxiety
|December 10, 2025
Summary
This study found that myopia is linked to a higher risk of mental disorders, including anxiety and depression. The findings suggest a potential two-way influence between myopia and mental health conditions.
Area of Science:
- Ophthalmology
- Psychiatry
- Public Health
Background:
- Myopia and mental disorders share common risk factors, but previous research on their association is inconsistent.
- Understanding the relationship between myopia and mental health is crucial due to shared environmental and behavioral influences.
Purpose of the Study:
- To systematically review and meta-analyze existing literature to explore the association between myopia and mental disorders.
- To quantify the risk of mental disorders in individuals with myopia and vice versa.
Main Methods:
- A systematic search of major databases (PubMed, Web of Science, Wiley, Cochrane) was conducted for studies published between January 2000 and July 2024.
- Included studies assessed the relationship between myopia and any mental disorder.
- Random-effects models were used to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- Fifteen articles involving over 2.8 million participants revealed that myopia is significantly associated with an increased risk of mental disorders (OR = 1.41, 95% CI: 1.23, 1.59).
- Eight articles with nearly 2 million participants showed a significant relationship between mental disorders and myopia (OR = 1.15, 95% CI: 1.01, 1.29).
- Subgroup analyses confirmed significant associations between myopia and anxiety (OR = 1.49) and depression (OR = 1.33).
Conclusions:
- Myopia and mental disorders may have a reciprocal influence, with each condition potentially increasing the risk of the other.
- The findings highlight a complex interplay between visual health and mental well-being, warranting further investigation.
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