Immunomodulatory Biomaterials for Implant Osseointegration: Knowledge Mapping (2005-2025)

Area of Science:

• Biomaterials Science
• Immunology
• Orthopedic Surgery

Background:

• Implant osseointegration is crucial for orthopedic success.
• Immunomodulatory biomaterials offer a promising strategy to enhance this process.
• A comprehensive understanding of the research landscape is needed.

Purpose of the Study:

• To map the research landscape of immunomodulatory biomaterials for implant osseointegration from 2005-2025.
• To identify temporal trends, key contributors, and emerging hotspots.
• To analyze collaboration, journal orientation, and translational bottlenecks.

Main Methods:

• Bibliometric analysis of publications from the Web of Science Core Collection.
• Identification of temporal trends, contributing countries, institutions, and journals.
• Analysis of cocitation networks and keyword evolution.

Main Results:

• 419 articles identified, with steady increases in output and citations.
• China, the United States, and Australia are leading contributors.
• '3D printing', 'scaffolds', and 'macrophage polarization' are recent hotspots, indicating a shift towards clinical translation.

Conclusions:

• The field has evolved from osteoimmunomodulation theory to nanoengineering and dynamic response design.
• Future research should focus on intelligent responsive biomaterials and multiomics validation.
• Accelerating the transition from passive repair to active regulation in bone regeneration is key.