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Detection of Novel HLA-B*35:01:86 and HLA-DRB1*15:243 Alleles

Maria Loginova1,2, Igor Paramonov1, Maksim Zarubin3

  • 1Federal State-Financed Scientific Institution: Kirov Research Institute of Hematology and Blood Transfusion Under the Federal Medical Biological Agency, Kirov, Russia.

HLA
|December 10, 2025
PubMed

Keywords:
HLA‐BHLA‐DRB1NGSnovel allele

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...