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Updated: Jan 9, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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DOCK2 in Disease: Emerging Insights and Research Advances

Zhaolong Yu1,2, Songzhi Jin1,2,3, Shujing Wan1,2

  • 1Key Laboratory of Innate Immunity and Chronic Inflammatory Diseases, Jiangxi Provincial Department of Education, Gannan Medical University, Ganzhou, China.

Immunological Investigations
|December 10, 2025
PubMed
Summary

DOCK2, a key protein, regulates immune and non-immune cells. Its dysregulation is linked to diseases like cancer and fibrosis, offering potential therapeutic targets.

Keywords:
DOCK2guanine nucleotide exchange factor (GEF)research progress

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