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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Pneumothorax-II01:27

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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Ferroptosis and Radiotherapy in Lung Cancer.

Prem C Patel1, Eva M Galvan1

  • 1Department of Radiation Oncology, University of Texas at San Antonio, San Antonio, TX 78229, USA.

Cells
|December 10, 2025
PubMed
Summary

Ferroptosis, a cell death process driven by iron, can enhance lung cancer treatment when combined with radiotherapy. This approach offers a promising strategy to overcome tumor radioresistance and improve patient outcomes.

Keywords:
ferroptosislung cancerradiation therapyradiotherapy

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Area of Science:

  • Oncology
  • Cell Death Mechanisms
  • Cancer Therapeutics

Background:

  • Lung cancer (LC) remains a major global cause of cancer mortality.
  • Radiotherapy (RT) is a standard LC treatment but faces challenges with tumor radioresistance and collateral damage.
  • Ferroptosis, a distinct form of programmed cell death, presents a novel therapeutic avenue.

Purpose of the Study:

  • To provide a comprehensive review of ferroptosis in the context of its synergy with radiotherapy for lung cancer treatment.

Main Methods:

  • Literature review focusing on ferroptosis mechanisms and their interaction with radiotherapy in lung cancer models.
  • Analysis of studies investigating pharmacologic agents that induce ferroptosis.

Main Results:

  • Ferroptosis is characterized by iron overload, reactive oxygen species generation, and cell membrane damage.
  • Lung cancer cell lines exhibit varied responses to ferroptosis induction.
  • Radiotherapy can act as a ferroptosis inducer, particularly when combined with agents like erastin.

Conclusions:

  • Ferroptosis is a promising adjunct to conventional radiotherapy for lung cancer.
  • Further research is needed to establish dosage standards, repurpose drugs, and develop safety protocols for clinical application.