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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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A compact depth-of-interaction time-of-flight detector panel dedicated for organ-specific PET scanner.

Mehdi Amini1, Abdollah Saberi Manesh1, Katayoun Doroud2

  • 1Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.

Physics in Medicine and Biology
|December 10, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a compact positron emission tomography (PET) detector panel with depth-of-interaction (DOI) and time-of-flight (TOF) capabilities. The developed detector panel offers a practical solution for next-generation organ-dedicated PET systems.

Keywords:
PETdepth of interactiondetector panelorgan-dedicated PETtime-of-flight

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Area of Science:

  • Medical Imaging
  • Nuclear Instrumentation
  • Particle Detectors

Background:

  • Dedicated positron emission tomography (PET) scanners require compact detector modules.
  • High depth-of-interaction (DOI) and time-of-flight (TOF) capabilities are crucial for advanced PET imaging.
  • Existing detector modules often face limitations in size, DOI, and TOF performance.

Purpose of the Study:

  • To design and evaluate a compact, ready-to-use PET detector panel.
  • To optimize the panel for organ-dedicated PET scanners needing high DOI and TOF.
  • To demonstrate a practical and easily calibratable solution for next-generation PET systems.

Main Methods:

  • Developed a 98.4 × 104.2 mm² panel with a 4 × 3 array of four-layer, dual-readout detector towers.
  • Utilized Lutetium Fine Silicate (LFS) crystals in an 8 × 4 × 1 array per tower.
  • Employed a side-irradiation configuration for DOI measurement and dual-ended readout for axial positioning.
  • Integrated a high-speed picoTDC-based electronic readout system for precise timing and amplitude measurements.
  • Performed crystal-level energy calibration using multiple isotopes and flood irradiation for axial positioning calibration.

Main Results:

  • Achieved average energy resolutions of 14.2% to 15.4% across four layers.
  • Demonstrated obtainable DOI and transaxial positioning steps of 4.4 mm and 2.05 mm, respectively.
  • Measured axial spatial resolutions ranging from 3.78 mm to 4.78 mm FWHM across layers.
  • Obtained TOF resolutions averaging 196 ± 7 ps to 220 ± 17 ps for different layer pairs.

Conclusions:

  • The developed PET detector panel balances performance, scalability, and manufacturability.
  • It provides a practical and easily calibratable solution for organ-dedicated PET systems.
  • The panel meets the requirements for high DOI and TOF capabilities in next-generation PET scanners.