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Updated: Jan 9, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Skin deep: Unconventional autophagy eats away TNF-driven skin inflammation

Ying Feng1, Francis Ka-Ming Chan1

  • 1Liangzhu Laboratory, Department of Cardiology, Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Transvascular Implantation Devices Research Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Immunity
|December 10, 2025
PubMed
Summary

Autophagy, regulated by ATG9A, suppresses skin inflammation by inhibiting STING activation and Z-DNA binding protein 1 (ZBP1)-dependent cell death, revealing a novel anti-inflammatory mechanism.

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