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Updated: Sep 10, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
Sensory nerves send lymphoid assembly up in smoke
1Krantz Family Center for Cancer Research, Massachusetts General Brigham Cancer Institute, Boston, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA.
Abstract:
Accumulating evidence implicates sensory neurons in tumor progression, but signals linking nociceptive activity to impaired antitumor immunity remain unclear. In a recent issue of Cell, Ho et al. show that nociceptor activation impedes TLS assembly through CGRP, and cigarette smoke engages this neuroimmune axis, promoting tumor growth independently of mutagenic effects.
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