Nodular Pulmonary Sarcoidosis with a B-cell Reaction Similar to That of IgG4-related Disease
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Updated: Jan 9, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Hirokazu Tokuyasu1, Shuichi Matsuoka1, Katsunori Arai1
1Respiratory Medicine Division, Matsue Red Cross Hospital, Japan.
Abstract:
A 66-year-old man presented to our hospital following the detection of abnormal chest shadows during a previous medical checkup. Chest computed tomography revealed multiple small nodules in both lungs, and surgical biopsy was performed for the diagnosis. A histological examination of the pulmonary nodules revealed small non-caseating epithelioid cell granulomas with prominent infiltration of lymphocytes and IgG4-positive plasma cells. The patient was eventually diagnosed with pulmonary sarcoidosis, with a B-cell response similar to that of IgG4-related disease. This report provides insight into sarcoidosis with histopathological features similar to those of IgG4-related diseases.
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