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ALKBH5 gene polymorphisms and Wilms tumour susceptibility in children from East China: a case-control study
Jiabin Yu1, Yizhen Wang2, Shouhua Zhang3
1Qingdao Women and Children's Hospital, Qingdao, China.
Insights
The ALKBH5 rs8400 G>A gene variant increases Wilms tumour risk in children. This finding highlights the role of ALKBH5 in paediatric renal malignancy susceptibility.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Wilms tumour is the most common paediatric kidney cancer.
- The ALKBH5 gene, involved in RNA modification, is implicated in cancer but its role in Wilms tumour is unclear.
Purpose of the Study:
- To investigate the association between ALKBH5 gene polymorphisms and Wilms tumour susceptibility.
Main Methods:
- A case-control study was conducted with 416 Wilms tumour patients and 936 controls from East China.
- Two ALKBH5 single-nucleotide polymorphisms (SNPs), rs1378602 G>A and rs8400 G>A, were genotyped.
Main Results:
- The rs8400 AA genotype was linked to a higher Wilms tumour risk (OR=1.39).
- Individuals with two risk genotypes had significantly increased risk (OR=1.43).
- Elevated risk was notable in children over 18 months, females, and those with early-stage disease (I/II).
Conclusions:
- The ALKBH5 rs8400 G>A polymorphism is associated with increased Wilms tumour susceptibility in Eastern Chinese children.
Background:
Wilms tumour is the most common paediatric renal malignancy. The RNA demethylase alkylation repair homologue protein 5 (ALKBH5), known for its role in reversing N6-methyladenosine modification, has been increasingly implicated in tumourigenesis. Its specific role in Wilms tumour, however, remains largely unexplored. We conducted a case-control study to investigate the association between ALKBH5 gene polymorphisms and susceptibility to Wilms tumour.
Methods:
Our study included 416 patients and 936 cancer-free controls from East China. We genotyped two ALKBH5 single-nucleotide polymorphisms: rs1378602 G>A and rs8400 G>A.
Results:
We found that the rs8400 AA genotype was significantly associated with an increased risk of Wilms tumour compared with GG/GA carriers (adjusted OR=1.39, 95% CI 1.04 to 1.85, p=0.025). Furthermore, individuals carrying two risk genotypes faced a significantly higher risk than those with zero or one risk genotype (adjusted OR=1.43, 95% CI 1.07 to 1.92, p=0.017). Stratified analysis revealed that this elevated risk was particularly pronounced in specific subgroups: children older than 18 months, females and those diagnosed with clinical stages I and II.
Conclusion:
Our findings suggest that the ALKBH5 rs8400 G>A polymorphism is associated with increased susceptibility to Wilms tumour in the Eastern Chinese paediatric population.
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