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Related Experiment Video

Updated: Jan 9, 2026

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Science-based safety assessment of genetically modified DP915635 maize.

Kent Brink1, Tim Gunderson1, Matthew Harmon1

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|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Genetically modified maize DP-915635-4, expressing the insecticidal IPD079Ea protein, was assessed for safety. Modernized evaluations confirmed its safety for food, feed, and the environment, protecting crops from corn rootworm.

Keywords:
Environmental risk assessmentgenetically modifiedinsecticidal proteinregulatory guidancesafety assessment

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Area of Science:

  • Agricultural Science
  • Biotechnology
  • Genetics

Background:

  • Corn rootworm infestations cause significant damage to maize crops.
  • Genetically modified (GM) crops offer a targeted approach to pest control.
  • Maize event DP-915635-4 was developed to express the IPD079Ea protein for insect resistance.

Purpose of the Study:

  • To assess the safety of genetically modified maize event DP-915635-4.
  • To evaluate the safety of the IPD079Ea protein for food, feed, and environmental use.
  • To demonstrate the efficacy of a modernized safety assessment model.

Main Methods:

  • Utilized the modernized safety assessment model by CropLife International (CLI).
  • Conducted molecular characterization of inserted DNA and protein expression analysis.
  • Performed safety assessments for food, feed, and environmental impact, including non-target organisms.

Main Results:

  • No hazards were identified for human or animal consumption of DP-915635-4 maize.
  • The IPD079Ea protein's safety was confirmed, negating the need for supplementary studies.
  • Environmental risk assessment indicated no unreasonable adverse effects on non-target organisms.

Conclusions:

  • Genetically modified maize event DP-915635-4 is safe for food, feed, and environmental use.
  • The modernized safety assessment model effectively demonstrates the safety of GM crop plants.
  • DP-915635-4 maize provides a viable solution for managing corn rootworm damage.