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Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Published on: October 10, 2013

Hyperbranched Aggregation-Induced Emission Luminogen-Based Sensor Array for Highly Sensitive Discrimination of

Shiyu Zang¹, Xiao Dong², Haozhi Song¹

¹School of Chemistry, Dalian University of Technology, Dalian 116024, PR China.

Analytical Chemistry

|December 11, 2025

Summary

This summary is machine-generated.

This study presents a novel fluorescent sensor array for simultaneously detecting 15 proteins with high sensitivity. This advancement offers a promising tool for point-of-care disease diagnosis.

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Area of Science:

Biochemistry
Analytical Chemistry
Materials Science

Background:

Simultaneous detection of multiple proteins is crucial for accurate disease diagnosis.
Existing sensor arrays often lack the required sensitivity and selectivity for complex biological samples.
Point-of-care diagnostics demand rapid, sensitive, and reliable protein detection methods.

Purpose of the Study:

To develop a highly sensitive fluorescent sensor array for simultaneous discrimination of multiple proteins.
To achieve low limits of detection for proteins, enabling early disease prediction.
To create a robust platform for point-of-care protein analysis.

Main Methods:

Fabrication of a fluorescent sensor array using three hyperbranched aggregation-induced emission (AIE) luminogens.
Utilizing multivalent interactions (electrostatic, hydrogen bond, van der Waals forces) for protein binding.
Employing linear discrimination analysis (LDA) for data processing and protein identification.

Main Results:

Simultaneous discrimination of 15 different proteins with a low limit of detection (0.05 μM).
Achieved 100% accuracy in protein detection and differentiation, including mixtures.
Demonstrated successful exclusion of interference from amino acids and inorganic salts.
Validated performance in complex biological samples like urine and serum.

Conclusions:

The developed sensor array offers a simple, cost-effective, and highly sensitive platform for protein analysis.
The AIE-based sensor array exhibits excellent selectivity, rapid response, and good repeatability.
This technology holds significant potential for point-of-care prediction and diagnosis of protein-related diseases.