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Updated: Jan 9, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules
Nilamoni Nath1, Juan Carlos Fuentes Monteverde2, Swaraj Pathak1
1Department of Chemistry, Gauhati University, Guwahati, India.
Abstract:
The determination of the relative and absolute configuration of natural compounds is a very challenging task. Among other anisotropic NMR parameters, residual chemical shift anisotropy (RCSA) induced by anisotropic media is an invaluable tool to determine relative configurations of natural and synthetic organic molecules in solution. This review introduces various RCSA-based methodologies for the structural elucidation of natural products. The current availability of alignment media in organic solvents for RCSA measurements is also discussed as are applications of RCSAs for structural analysis of various natural products.
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