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Updated: Jan 9, 2026
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
Published on: May 9, 2025
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Tumor-localized immunomodulation: a critical advance in engineering CAR-t cells for solid malignancies
Maryam Abid1, Ursula Abu Nahla2, Muhammad Nabeel Saddique1
1Department of Radiotherapy and Medical Oncology, King Edward Medical University, Lahore, Pakistan.
Annals of Medicine and Surgery (2012)
|December 11, 2025
Summary
Engineered CAR-T cells with linked anti-PD-L1 and IL-12 antibodies improve solid tumor treatment by localizing therapy and reducing toxicity. This innovation enhances antitumor responses and T cell infiltration in preclinical models.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Chimeric antigen receptor (CAR)-T cell therapy shows promise in hematological cancers but faces challenges in solid tumors.
- Solid tumors possess immunosuppressive microenvironments and combination immunotherapies can cause systemic toxicities.
- Current CAR-T cell limitations hinder effective treatment of solid malignancies.
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