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Ivabradine in acute care: Revisiting the funny current in critical care context

Arun Mukesh1, Ankur Sharma2, Nikhil Kothari3

  • 1Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342008, Rājasthān, India.

World Journal of Critical Care Medicine
|December 11, 2025
PubMed

Ivabradine, a selective inhibitor of the funny current in the sinoatrial node, has emerged as a promising agent for heart rate modulation in acute and critical care settings. Unlike beta-blockers, ivabradine reduces heart rate without affecting myocardial contractility, making it a valuable option for patients contraindicated for traditional therapies. This review examines its mechanism of action, clinical applications, comparative efficacy, and safety profile. It incorporates recent literature to assess its expanding role in managing acute coronary syndrome, acute decompensated heart failure, and sepsis-induced tachycardia.

Keywords:
Acute careBeta blockerHeart failureHeart rate controlIvabradineTachycardia

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