Risk Factors and Prognostic Significance of Non-Perioperative Atrial Fibrillation in Lung Cancer Patients

Area of Science:

• Cardiology
• Oncology
• Pulmonology

Background:

• High incidence of atrial fibrillation (AF) observed in lung cancer patients.
• Clinical and prognostic significance of non-perioperative AF remains unclear.

Purpose of the Study:

• Investigate the incidence and risk factors of non-perioperative AF in lung cancer patients.
• Determine the prognostic impact of non-perioperative AF on overall survival.

Main Methods:

• Retrospective single-center cohort study.
• Included 383 consecutive primary lung cancer patients.
• Analyzed baseline characteristics, AF development, and survival rates using propensity score matching.

Main Results:

• 27 patients (7.04%) developed non-perioperative AF.
• High C-reactive protein (CRP) was an independent risk factor for AF (OR 3.08).
• Non-perioperative AF was associated with significantly lower overall survival, despite mild symptoms.

Conclusions:

• Non-perioperative AF is common in lung cancer patients and linked to high CRP.
• Non-perioperative AF portends a worse prognosis, with lower survival rates.
• Body mass index (BMI) is a significant predictor of mortality in AF patients.