Radiotherapy and precision medicine's role in molecular alterations during chromosomal division: The influence of MB,

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Saloomeh Khoushab1,2, Mina Hobabi Aghmiuni1,2, Anahita Bizhanpour1,3

  • 1Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital, Faculty of Medicine, TeMS.C., Islamic Azad University, Tehran, Iran.

Biochemistry and Biophysics Reports
|December 11, 2025
PubMed

Insights

This study identifies key genes and microRNAs (miRNAs) as potential biomarkers for early oral cancer diagnosis and prognosis. Targeting these molecules may improve treatment efficacy and patient outcomes in oral cancer care.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oral cancer presents a significant global health challenge with high mortality rates.
  • Late diagnosis and the absence of effective biomarkers impede successful patient outcomes.
  • Understanding the molecular underpinnings of oral cancer is crucial for developing improved diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate specific genes (MB, TP53, CENPA, BUB1B, MAD2L, ZWINT) and microRNAs (hsa-mir-607, hsa-mir-556-5p, hsa-mir-1225-3p, hsa-mir-361-3p) as prognostic markers and therapeutic targets for oral cancer.
  • To elucidate the role of these genes and miRNAs in regulating cell cycle, DNA repair, and apoptosis in oral cancer.
  • To identify potential biomarkers for early diagnosis and prognosis, and explore novel therapeutic strategies.

Main Methods:

  • Analysis of gene and microRNA expression patterns in oral cancer tissues versus adjacent normal tissues.
  • Investigating the correlation between the expression of selected genes and microRNAs and oral cancer progression.
  • Exploring the potential of targeting these molecules to enhance radiation therapy efficacy.

Main Results:

  • Identification of specific genes and microRNAs with altered expression in oral cancer tissues.
  • Establishment of potential correlations between molecular markers and oral cancer prognosis.
  • Preliminary insights into the therapeutic potential of targeting identified genes and microRNAs.

Conclusions:

  • The investigated genes and microRNAs show promise as diagnostic and prognostic biomarkers for oral cancer.
  • Targeting these molecular entities could represent a novel therapeutic avenue for oral cancer.
  • This research contributes to personalized medicine approaches for oral cancer treatment.
Keywords:
Oral cancerPrecision medicinePrognostic markersRadiotherapy

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