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Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases
Xiaoyuan Bai1, Yiyuan Zhang2, Jing Qu3
1Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
JACC. Asia
|December 11, 2025
Summary
Cardiovascular aging (CVA) and cardiovascular diseases (CVDs) share common mechanisms. Targeting CVA offers a promising strategy for preventing, diagnosing, and treating CVDs, especially in aging populations.
Area of Science:
- Gerontology
- Cardiology
- Molecular Biology
Background:
- Cardiovascular diseases (CVDs) are the primary cause of global mortality, disproportionately affecting aging populations.
- Aging induces progressive cardiovascular remodeling, increasing susceptibility to cardiovascular pathologies.
- Understanding the interplay between cardiovascular aging (CVA) and CVDs is crucial for public health.
Purpose of the Study:
- To review the structural, functional, and molecular hallmarks of CVA and CVDs.
- To highlight the mechanistic convergence between CVA and CVDs.
- To discuss diagnostic biomarkers and interventions bridging CVA and CVDs.
Main Methods:
- Literature review of current research on cardiovascular aging and diseases.
- Analysis of structural, functional, and molecular changes associated with aging and CVDs.
- Synthesis of information on biomarkers and therapeutic strategies.
Main Results:
- Identified shared hallmarks and mechanistic pathways between CVA and CVDs.
- Established a translational continuum linking CVA and CVDs.
- Highlighted the potential of targeting CVA for CVD management.
Conclusions:
- Cardiovascular aging and cardiovascular diseases are mechanistically intertwined.
- Targeting cardiovascular aging presents a viable strategy for CVD prevention, early detection, and treatment.
- Further research into the CVA-CVD continuum can improve cardiovascular health outcomes in aging individuals.
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