A Highly Stable Lanthanide-Organic Framework for Ultrasensitive Dynamic Luminescence Detection of Quercetin

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Quercetin exhibits significant cardiovascular benefits, but its detection in complex matrices is hindered by weak interactions.
• Developing robust methods for sensitive quercetin detection is crucial for its therapeutic applications.

Purpose of the Study:

• To synthesize a stable lanthanide-organic framework (HBNU-21-Eu) for efficient luminescence-based quercetin detection.
• To establish a rapid and sensitive analytical method for quantifying quercetin in environmental and food samples.

Main Methods:

• Solvothermal synthesis of a mixed ligand lanthanide-organic framework using Eu3+ ions, H4BETC, and H2NDC.
• Characterization of the framework's stability (pH, solvent, thermal) and luminescence properties.
• Development of a dynamic quenching-based luminescence assay for quercetin detection.

Main Results:

• The synthesized HBNU-21-Eu framework demonstrated excellent stability and intense red luminescence (70.2% quantum yield).
• Rapid detection of quercetin was achieved within 30 seconds, with a low detection limit of 0.57 μM.
• The method showed high quenching efficiency (5.08 × 10^4 M^-1) and was successfully applied to tap water and jasmine tea samples with good recovery rates.

Conclusions:

• The HBNU-21-Eu framework provides a highly stable and sensitive platform for luminescence detection of quercetin.
• This method offers a rapid and efficient approach for quercetin analysis in real-world samples, overcoming previous detection challenges.