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Updated: Jan 8, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
RETRACTED: Efficacy and adherence of mobile health-based myofunctional therapy for obstructive sleep apnea
Liqun Zhu1, Wenqian Zhong2, Meihong Zhang3
1Department of Otolaryngology Head and Neck Surgery, South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong Province 518116, China; Department of Otolaryngology Head and Neck Surgery, the Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province 518035, China; Shenzhen Clinical Medical Research Center for Otolaryngology Diseases, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province 518035, China.
Objective:
To assess the impact of WeChat applet-based myofunctional therapy (MFT) on the efficacy and adherence of patients with obstructive sleep apnea (OSA) compared to conventional hospital-guided programs.
Methods:
A parallel-group randomized controlled trial was conducted, enrolling 78 patients with OSA who declined continuous positive airway pressure (CPAP) or surgical treatment (mean age 39.44 ± 9.82 years). Participants were randomly allocated to either the mini-program intervention group (n = 39) or the non-intervention group (n = 39). Both groups underwent a 12-week oropharyngeal muscle training program that targeted the soft palate, tongue, lips, and buccal muscles. The intervention group received video-based guidance, real-time feedback, and automated compliance monitoring via a customized WeChat application, whereas the non-intervention group maintained their records using paper diaries. Outcomes, including polysomnography results, sleep scale scores, and compliance rates, were subsequently compared between the two groups.
Results:
Sixty-six patients completed the study (32 in the intervention group and 34 in non-intervention group). Improvement in AHI was significantly better in the intervention group than in the non-intervention group (Δ8.92±9.27 vs. Δ2.66±6.80 beats/hour, P < 0.001), and adherence rates were higher at all time points (12 weeks: 73 % vs. 66 %, P = 0.002).
Conclusions:
Mobile health guided MFT significantly improved treatment adherence in patients with OSA and outperformed traditional modality in terms of improvement in the core metric AHI, providing a digital solution for CPAP-intolerant patients.
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