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Repeated visual perceptual micro-training enhances neural microplasticity in children with ametropic amblyopia: A
Fang-Fang Lan1, Wu-Xiao Zhao1, Lu Gan1
1Department of Optometry, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Objective:
The aim of this study was to evaluate the effects of repeated visual-perceptual micro training on neural microplasticity in children diagnosed with ametropic amblyopia, with a focus on changes in best-corrected visual acuity (BCVA), binocular visual function, and suppression.
Methods:
A total of 35 children with ametropic amblyopia (mean age: 6.80 years) underwent intervention using a binocular visual perceptual neural plasticity training system. The training protocol consisted of 20 sessions, administered five times per week, each lasting 40 min. BCVA, suppression status, and stereopsis were assessed at baseline (T0), after five sessions (T1), after ten sessions (T2), and 4 weeks post-intervention (T3).
Results:
Following ten training sessions, the mean BCVA improved from 0.72 to 0.88 in the right eye and from 0.70 to 0.90 in the left eye (p < 0.001). The prevalence of foveal suppression decreased from 51.43 % to 14.29 %, while the proportion of participants without suppression increased from 34.29 % to 57.14 % (p = 0.025). Significant improvements in fine stereopsis were observed at both 0.8 m and 1.5 m distances, with the proportion of individuals reaching grade 3-4 increasing to 82.86 % and 71.43 %, respectively (p < 0.01). The observed therapeutic effects remained stable throughout the follow-up period.
Conclusion:
Repeated visual perceptual micro-training demonstrated significant improvements in BCVA, binocular visual function, and suppression in children with ametropic amblyopia. These effects followed a cumulative enhancement pattern and remained stable during the 4-week post-training follow-up period, suggesting potential clinical applicability in amblyopia rehabilitation while highlighting the need for longer-term evaluation.
