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Updated: Jan 8, 2026

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TfOH-Promoted Cascade Reaction of Nitriles and 1,5-Enynes: An Efficient Route to Amido-Functionalized Fluorenes
Babasaheb Sopan Gore1, Wan-Jing Liu1, Lin-Wei Pan1
1Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan first Rd, Sanmin District, Kaohsiung City 807, Taiwan.
Abstract:
We have demonstrated a highly efficient synthetic strategy for assembling amide-functionalized fluorenes via cascade reactions between nitriles and 1,5-enynes in a one-pot assembly. This approach provides a simple, atom-economic, practical, and robust path to synthesize highly versatile rare carbocyclic scaffolds under transition-metal- and additive-free conditions with good reaction yields. Its most noteworthy features include high compatibility with various functionalities, mild conditions, easily accessible precursors, and gram-scale synthesis.
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