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Oxidative stress in metastatic progression.

Yoshifumi Ueda1, Shigeki Kiyonaka2, Yasuo Mori1

  • 1Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.

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|December 11, 2025
PubMed
Summary

Cancer cells utilize oxidative stress and reactive oxygen species (ROS) to survive and spread during metastasis. Therapies targeting these redox dynamics could combat cancer spread and mortality.

Keywords:
NRF2antioxidantcirculating tumor cells (CTCs)disseminationepithelial–mesenchymal transition (EMT)reactive oxygen species (ROS)

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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Metastasis is the primary driver of cancer mortality.
  • Tumor cells must adapt to hostile microenvironments during metastatic spread.
  • Oxidative stress, caused by reactive oxygen species (ROS), is a critical factor influencing metastasis.

Purpose of the Study:

  • To review how cancer cells respond to oxidative stress during metastasis.
  • To delineate the roles of ROS in the metastatic cascade.
  • To explore therapeutic strategies targeting redox dynamics in metastatic cancer.

Main Methods:

  • Literature review of studies on cancer metastasis and oxidative stress.
  • Analysis of the mechanisms by which tumor cells manage ROS.
  • Exploration of therapeutic interventions targeting redox pathways.

Main Results:

  • Cancer cells employ adaptive mechanisms to cope with oxidative stress.
  • ROS play multifaceted roles, supporting survival and promoting metastatic traits.
  • Redox signaling is crucial for tumor cell adaptation and progression.

Conclusions:

  • Understanding cellular responses to oxidative stress is key to inhibiting metastasis.
  • Targeting ROS and redox balance presents a promising therapeutic avenue.
  • Disrupting redox dynamics offers a strategy to overcome metastatic disease challenges.