Concentrated Growth Factors and Bone Grafting in Maxillary Sinus Lift: A Systematic Review

This review evaluates the latest studies on the effectiveness of growth factor concentrates and bone grafts (BGs) in maxillary sinus lift (MSL) procedures, emphasizing their role in bone regeneration and healing. The aim is to determine their impact on enhancing clinical outcomes by improving bone quality and accelerating the healing process.

A comprehensive literature search was conducted using the Scopus, Web of Science, and PubMed databases. The following keywords were employed: "PRP," "L-PRF," "CGF," "oral surgery," and "sinus lift," combined with the Boolean operators "AND" and "OR." A total of 727 studies were initially identified, of which 18 met the inclusion criteria for this review.

The included studies demonstrate that the use of growth factors in conjunction with alloplastic and xenogeneic BGs significantly promotes early vascularization and has potent proangiogenic effects in vivo. Furthermore, these combinations reduce postoperative inflammation and discomfort, accelerating the healing process and enhancing tissue regeneration.

Although further research is necessary, current evidence suggests that autologous platelet concentrates hold promise for improving clinical outcomes in MSL procedures. They may enhance bone height and thickness, improve vascularization, and expedite postoperative healing, offering a valuable adjunct to traditional bone grafting techniques in oral surgery.