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Rucaparib in refractory pleural mesothelioma harboring somatic pathogenic BRCA1 and BRCA2 mutation. A report of two

Luigi Cerbone1, Benedetta Del Rio2, Sara Delfanti1

  • 1Azienda Ospedaliera Universitaria SS Antonio e Biagio e Cesare Arrigo - Mesothelioma, melanoma and rare cancer unit, Alessandria, Italy.

Lung Cancer Management
|December 12, 2025
PubMed

Insights

Rucaparib shows promise for pleural mesothelioma patients with BRCA mutations. This targeted therapy offers clinical benefit in refractory cases, highlighting the importance of genetic testing for treatment selection.

Area of Science:

  • Oncology
  • Genetics

Background:

  • Pleural mesothelioma is a rare cancer with limited treatment options, particularly for refractory cases.
  • Targeted therapies have shown minimal benefit, but actionable mutations may exist in a subset of patients.

Purpose of the Study:

  • To report clinical benefit of rucaparib in heavily pretreated pleural mesothelioma patients with BRCA mutations.

Main Methods:

  • Next-generation sequencing (NGS) was used to detect somatic BRCA1 and BRCA2 mutations.
  • Two patients with advanced pleural mesothelioma received rucaparib treatment.

Main Results:

  • Both patients with BRCA1/2 mutations experienced significant clinical benefit from rucaparib.
  • This suggests rucaparib's efficacy in a specific molecular subtype of mesothelioma.

Conclusions:

  • Somatic BRCA1/2 mutations can be actionable targets in pleural mesothelioma.
  • Rucaparib may be a viable therapeutic option for patients with these mutations, warranting further investigation.
Keywords:
PARP inhibitorscancergeneticsmesotheliomametastasisnovel therapyoncogene

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