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Updated: Jan 8, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
Published on: December 17, 2018
A valence-state-defect-mediated copper nanocluster nanozyme with high peroxidase-like activity for multimodal
Zhong-Xia Wang1, Peng Shan1, Ze-Yu Sun1
1School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu, 224051, P.R. China. wangzx198411@163.com.
Abstract:
Nanozyme-based colorimetric analysis has potential applications in environmental monitoring and food safety. Here, we report a novel copper nanocluster (CuNC) nanozyme with high peroxidase-like activity. The results demonstrate exceptional catalytic activity of up to 114.29 U mg-1 in the presence of high oxidation state Cu2+ species. Accordingly, a CuNC-based colorimetric platform was established for high selectivity Hg2+ monitoring with a limit of detection of 4.21 nM. Excitingly, the color change induced by Hg2+ can be detected not only with the naked eye but also using a smartphone, without the need for sophisticated instruments or trained personnel. This work not only provides an economical and reliable multimodal detection method for Hg2+ but also enriches the existing armory of nanozymes in colorimetric studies and beyond.
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