Related Experiment Video
Updated: Jan 8, 2026

06:38
In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
936
Fine Motor Development Growth Curves for Down Syndrome
Mandie Wiebers Jensen1, Margaret Wolf2, Alicia Feryn3
1Neurodevelopmental Pediatrics / Institute on Development and Disability, Oregon Health & Science University, Portland, OR, USA.
Journal of Child Neurology
|December 12, 2025
Summary
This study created growth curves for fine motor skills in children with Down syndrome (DS). Despite initial delays, grasping and visual motor skills improve with age in children with DS.
Area of Science:
- Developmental Pediatrics
- Neurodevelopmental Disorders
- Motor Development
Background:
- Children with Down syndrome (DS) often exhibit delays in fine motor skills.
- Understanding typical developmental trajectories is crucial for identifying and supporting children with DS.
Purpose of the Study:
- To develop normative growth curves for fine motor development in children with Down syndrome.
- To specifically assess grasping and visual motor integration skills.
- To provide tools for early identification and intervention.
Main Methods:
- Retrospective chart review of a large cohort of children with Down syndrome.
- Data collected from the Peabody Developmental Motor Scales-2nd Edition (PDMS-2).
- Analysis of children from birth to 6 years of age.
Main Results:
- Children with Down syndrome showed delayed fine motor and visual motor development compared to typically developing peers.
- Grasping and visual motor integration raw scores demonstrated an increase with age.
- A negative association was observed between fine motor quotient and age.
Conclusions:
- The developed Down syndrome-specific percentile curves can aid in identifying children needing further assessment.
- These curves will be valuable for future research on factors influencing fine motor development in DS.
- The data can help parents interpret developmental test results and understand their child's progress.
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