Signaling pathways shaping the field of lipidomics

Area of Science:

• Lipidomics and molecular biology
• Cellular signaling and metabolism

Background:

• Lipidomics is crucial in biology and medicine, extending beyond metabolic disorders to developmental biology, ecology, and evolution.
• Interpreting lipidomics data at the molecular level, especially via signaling pathways, presents a significant challenge.
• A comprehensive overview of lipid-regulating signaling pathways is lacking in current literature.

Purpose of the Study:

• To systematically compile signaling pathways involved in lipid metabolism and lipid-based biological processes.
• To explore the significance of these pathways in lipidomics research and interpretation.
• To provide a guide for understanding lipid-mediated mechanisms in diverse biological contexts.

Main Methods:

• Literature review and synthesis of signaling pathways.
• Categorization of pathways based on their role in lipid metabolism and signaling.
• Discussion of molecular roles and potential impacts across research fields.

Main Results:

• A structured catalogue of signaling pathways regulating or influenced by lipid signals is presented.
• Pathways cover fundamental lipid metabolism, lipid-based processes, and emerging lipid-dependent mechanisms.
• Each pathway's molecular roles in lipidomics and cross-disciplinary impact are discussed.

Conclusions:

• This review bridges the gap in understanding lipid signaling pathways within lipidomics.
• It serves as a valuable resource for interpreting lipidomics data and identifying research targets.
• The compilation fosters integration of lipidomics into broader biological studies, advancing lipid-mediated process understanding.