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Updated: Jan 8, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Published on: May 26, 2019

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1,5-Conjugate Addition: A Potentially Valuable Synthetic Tool

Jing-Ming Zhang1,2, Shi-Feng Tao1,2, Xing-Kai Zhao1,2

  • 1School of Chemistry and Materials Science, Hangzhou Institute For Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 12, 2025
PubMed
Summary

Umpolung 1,5-conjugate addition, rarely explored due to electronic mismatch, is now feasible using palladium hydride catalysis. This breakthrough enables enantioselective introduction of nucleophiles and synthesis of cyclic structures, establishing a new synthetic model.

Keywords:
1,5‐conjugate additionasymmetric synthesiscascadepalladium catalystumpolung

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