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Generalized Linear Porokeratosis Treated With Ixekizumab.
Yihe Zheng1, Yunhao Zhu2, Jianjun Qiao1
1Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The Journal of Dermatology
|December 12, 2025
Summary
Ixekizumab effectively treated extensive linear porokeratosis (LP) in a young patient, achieving near-complete lesion clearance. While skin lesions responded well, nail dystrophy showed limited improvement, suggesting targeted therapy potential for refractory LP.
Area of Science:
- Dermatology
- Immunology
- Clinical Therapeutics
Background:
- Linear porokeratosis (LP) is a rare, chronic skin disorder.
- Treatment options for extensive or refractory LP are limited.
- The role of interleukin-17A (IL-17A) in LP pathogenesis is under investigation.
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