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Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Published on: February 23, 2024

Visual Function Assessment in Geographic Atrophy: A Review.

Ye Li¹, Lauren N Ayton^2,3,4, Adrian T Fung^5,6,7,8

¹Department of Ophthalmology, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Clinical & Experimental Ophthalmology

|December 12, 2025

Summary

This summary is machine-generated.

Geographic atrophy (GA) significantly impacts vision and quality of life. This review highlights the need for robust visual function tests, beyond structural imaging like fundus autofluorescence (FAF), to accurately assess GA progression and treatment efficacy.

Keywords:

functional vision geographic atrophy vision function

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Area of Science:

Ophthalmology
Medical Imaging
Clinical Trials

Background:

Geographic atrophy (GA) leads to severe vision impairment and reduced quality of life.
Fundus autofluorescence (FAF) is standard for GA assessment but is a surrogate for vision loss.
Current visual function tests like best-corrected visual acuity (BCVA) are inadequate for tracking GA progression.

Purpose of the Study:

To review the association between FAF and visual function tests in GA patients.
To emphasize the importance of functional vision assessment in GA clinical trials.
To guide the selection of appropriate endpoints for evaluating GA treatments.

Main Methods:

Literature review focusing on the correlation between FAF imaging and various visual function tests.
Analysis of existing data on tests including low luminance visual acuity (LLVA), reading speed, and microperimetry.
Examination of patient-reported outcomes for functional vision assessment.

Main Results:

FAF is a structural marker, but visual function tests provide a more direct measure of vision loss in GA.
Standard BCVA is often confounded by GA's late-stage foveal involvement and slow progression.
A variety of functional vision tests show promise for better GA assessment.

Conclusions:

Future GA clinical trials require a comprehensive suite of visual function endpoints.
Focusing on rapidly progressing GA lesion phenotypes will enhance the detection of treatment benefits.
Accurate functional vision assessment is crucial for regulatory approval of new GA therapies.