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Updated: Jun 21, 2026

3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
Published on: April 15, 2021
Transient apical breakdown during orthodontic incisor intrusion treated with non-steroidal anti-inflammatory drugs: a
Masato Kaku1, Saiji Shimoe2, Yuichi Mine3
1Department of Anatomy and Functional Restorations, Division of Oral Health Sciences, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-0037, Japan. mkaku@hiroshima-u.ac.jp.
Abstract:
Transient apical breakdown (TAB) may occur during pulp repair after dental traumatic injury, including orthodontic force. Herein, we describe TAB in the maxillary right central incisor of a 24-year-old woman during orthodontic treatment for a severe gummy smile. Eight months after initiating intrusion of the maxillary anterior teeth using temporary anchorage devices, the maxillary right central incisor showed discoloration and was non-responsive to electric pulp tests. The orthodontic force on the maxillary anterior teeth was immediately removed, and loxoprofen sodium, a non-steroidal anti-inflammatory drug (NSAID), was administered three times a day for seven days. Six months after removal of the orthodontic force, the crown colour improved and the tooth regained sensitivity to electric pulp testing. Therefore, orthodontic treatment was resumed and was completed two years after initiation. Obliteration of the root canal of the maxillary right central incisor was observed during a four-year-retention period. The findings in this case suggest that removal of orthodontic force and administration of NSAIDs are possibly useful for improving TAB following traumatic pulp injury due to orthodontic treatment.
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