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Engineering Biocompatible Metal-Based Nanoparticles for Advanced Antibacterial Therapy.

Jiwon Kim1, Khongorzul Enkhtaivan1, Minje Kim1

  • 1School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea.

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|December 13, 2025
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Summary
This summary is machine-generated.

Engineered metal-based nanoparticles (MNPs) show promise as novel antibacterial agents against antibiotic-resistant bacteria. Strategies are being developed to improve their biocompatibility and reduce toxicity for clinical applications.

Keywords:
antibacterial agentsantibioticscytotoxicitynanoparticlessurface chemistry

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Area of Science:

  • Nanomedicine
  • Materials Science
  • Infectious Diseases

Background:

  • Antibiotic resistance is a critical global health threat, necessitating alternative treatments.
  • Metal-based nanoparticles (MNPs) offer broad-spectrum antibacterial activity with low resistance potential.
  • Current MNPs face challenges with cytotoxicity and biocompatibility, limiting clinical use.

Purpose of the Study:

  • To review recent advancements in designing biocompatible MNPs for infection treatment.
  • To explore strategies for enhancing MNP efficacy and safety.
  • To discuss the potential of engineered MNPs as next-generation therapeutics.

Main Methods:

  • Summarizing research on rational design and surface modification of MNPs.
  • Analyzing functionalization techniques to improve biocompatibility and antibacterial action.
  • Reviewing studies on minimizing off-target toxicity of MNPs.

Main Results:

  • Engineered MNPs demonstrate improved biocompatibility without sacrificing antibacterial efficacy.
  • Surface modification and rational design are key to overcoming MNP limitations.
  • Various mechanisms of antibacterial action for MNPs have been identified.

Conclusions:

  • Engineered MNPs represent a promising therapeutic strategy against multidrug-resistant infections.
  • Further research into MNP design and clinical translation is warranted.
  • Biocompatible MNPs offer a potential solution to the growing antibiotic resistance crisis.