Fe(III)-Anchored Porphyrin-Based Covalent Organic Framework as a Potent Catalyst for Biginelli Reaction
Shivani Bhagat1, Pranjal Singh1, Sushree S Nayak1
1Department of Chemistry, Visvesvaraya National Institute of Technology (VNIT), Nagpur, Maharashtra, India.
Chempluschem
|December 13, 2025
Summary
We developed a novel iron-functionalized covalent organic framework (Fe@AP-COF) for efficient catalysis. This robust material demonstrates excellent recyclability and superior performance in synthesizing dihydropyrimidinones via the Biginelli reaction.
Area of Science:
- Materials Science
- Catalysis
- Organic Chemistry
Background:
- Covalent organic frameworks (COFs) offer tunable porosity and functional groups for metal immobilization.
- Porphyrin-based COFs provide a stable scaffold for catalytic centers.
Purpose of the Study:
- To synthesize and characterize Fe(III)-impregnated porphyrin-based COFs (Fe@AP-COF).
- To evaluate the catalytic performance of Fe@AP-COF in the Biginelli reaction.
Main Methods:
- Schiff-base condensation for AP-COF synthesis.
- Immobilization of Fe(III) ions into the AP-COF matrix.
- Characterization using TEM, dark field imaging, and surface area analysis.
- Catalytic testing of Fe@AP-COF in the Biginelli multicomponent reaction.
Main Results:
- Fe@AP-COF exhibited homogeneous dispersion of Fe(III) ions.
- The catalyst showed excellent thermal robustness, high surface area, and structural integrity.
- Fe@AP-COF demonstrated high efficiency and recyclability in DHPM synthesis with minimal Fe leaching.
- Superior catalytic activity compared to homogeneous and conventional heterogeneous Fe catalysts.
Conclusions:
- Metal-functionalized porphyrin-based COFs are effective platforms for catalysis.
- Fe@AP-COF presents a promising, adaptable, and efficient heterogeneous catalyst.
- This work highlights the potential of COFs in advanced catalytic applications.
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