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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Updated: Jan 8, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Obesity in China: current progress and future prospects.

Xiong-Fei Pan1, Zhong-Ze Fang2, Lingli Zhang3

  • 1Section of Epidemiology and Population Health and Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children and Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

The Lancet. Diabetes & Endocrinology
|December 13, 2025
PubMed
Summary
This summary is machine-generated.

Obesity rates are rising in China, despite new treatments like GLP-1 receptor agonists. Key challenges include diagnostic criteria, national targets, and evidence-based treatment algorithms for effective obesity care.

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Area of Science:

  • Public Health
  • Clinical Research
  • Health Policy

Background:

  • Rising prevalence of overweight and obesity in China.
  • Significant health and economic consequences associated with obesity.
  • Increasing focus on obesity as a national public health issue.

Purpose of the Study:

  • Critically examine recent advances in obesity management.
  • Identify current and emerging challenges in public health, policy, and clinical practice.
  • Propose integrated, people-centered systems for comprehensive obesity care.

Main Methods:

  • Review of national policy frameworks and technical guidelines.
  • Analysis of evidence for lifestyle interventions and pharmacotherapy.
  • Examination of approved GLP-1 receptor agonists for weight management in China.

Main Results:

  • National policies and guidelines have raised obesity awareness.
  • New GLP-1 receptor agonists offer expanded therapeutic options.
  • Challenges persist in diagnostic criteria, national targets, and pharmacotherapy algorithms.

Conclusions:

  • Progress in obesity care is threatened by persistent challenges.
  • Need for integrated systems addressing socioeconomic, environmental, and behavioral factors.
  • Call for whole-person obesity care within a planetary health framework.