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Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study
Han-Cheng Yu1,2, Ji-Juan Zhang3,4, Jin-Jin Zhang3,4,5
1Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Infections are common in type 2 diabetes (T2D). Lifestyle and socioeconomic factors, along with central obesity, significantly increase infection risk, highlighting the need for comprehensive management strategies.
Area of Science:
- Diabetes Mellitus Research
- Infectious Disease Epidemiology
- Public Health
Background:
- Infection poses a significant health risk for individuals with diabetes.
- Comprehensive risk factor assessments for infections in diabetes populations are limited.
Purpose of the Study:
- To identify risk factor profiles associated with infections in people with type 2 diabetes (T2D).
- To quantify the contribution of individual risk factors and their domains to infection incidence.
Main Methods:
- Prospective cohort study of 24,021 participants with T2D.
- Analysis of 28 risk factors across socioeconomic, lifestyle, environmental, psychological, clinical, and comorbidity domains.
- Negative binomial regression and population attributable fraction (PAF) calculations.
Main Results:
- Nineteen risk factors were significantly associated with increased infection risk.
- Central obesity was the leading individual risk factor (PAF, 13.2%).
- Lifestyle factors (32.7%) and socioeconomic status (26.3%) were the largest contributors to total infections.
Conclusions:
- A wide range of risk factors contribute to infections in adults with T2D.
- Comprehensive management strategies are crucial for infection prevention in this population.
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