Leveraging cancer metabolism to translate into effective therapeutics

Abnormal metabolism is a typical characteristic of malignant tumors, broadly influencing the outcome of cancer therapy. Research on tumor metabolism has increased exponentially in last decades. There is an urgent need to provide a blueprint or framework to accelerate the translation of cancer metabolism research into effective therapeutics. In this review, we summarize the impact of metabolism on cancer progression and emerging metabolic therapies, and systematically outline potential clinical applications in cancer prevention, early screening, diagnosis, treatment, and new challenges. Furthermore, we aim to provide researchers and clinicians with a clearer perspective on the immediate translation of clinical applications stemming from cancer metabolism research. It will revolutionize cancer management and significantly enhance patient survival.