Related Experiment Video

Updated: Jan 8, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K

Atopic diseases in pediatric population: prematurity and small for gestational age

Yi-Yu Su1,2, Chi-Jen Chen3, Mei-Huei Chen4,5

  • 1Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Room 733, 17 Xu-Zhou Road, Taipei, 10055, Taiwan.

BMC Pediatrics
|December 13, 2025
PubMed

Insights

Prematurity increases risks for asthma and allergic rhinitis in children but lowers atopic dermatitis risk. Small-for-gestational-age status showed no link to these pediatric atopic diseases.

Area of Science:

  • Pediatric Health
  • Allergy and Immunology
  • Perinatal Medicine

Background:

  • Atopic diseases (asthma, atopic dermatitis, allergic rhinitis) are common in children.
  • Prematurity and small-for-gestational-age (SGA) status impact long-term health.
  • Understanding these links is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between prematurity, SGA status, and atopic disease development in children.
  • To analyze risks of specific atopic conditions in relation to birth status.

Main Methods:

  • Utilized Taiwan's National Health Insurance Research Database (NHIRD) for a nationwide longitudinal cohort.
  • Included over 1.7 million infants born between 2004-2019.
  • Employed Kaplan-Meier analysis and Cox proportional hazards models for risk assessment, adjusting for covariates.

Main Results:

  • Premature infants showed increased risks for allergic rhinitis (AR) and asthma.
  • Prematurity was associated with a decreased risk of atopic dermatitis (AD).
  • Small-for-gestational-age (SGA) status in term infants was not linked to atopic diseases.

Conclusions:

  • Prematurity is a significant factor for developing certain pediatric atopic diseases.
  • SGA status in term infants does not appear to influence atopic disease risk.
  • Further research is needed to elucidate mechanisms and causality.
Abstract

Keywords:
Allergic rhinitisAsthmaAtopic dermatitisPrematuritySmall for gestational age

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.8K
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

506

Related Concept Videos

Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
64.1K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
229
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
240
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
194
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
231