Related Experiment Video
Updated: Aug 12, 2026

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
Published on: October 11, 2017
Lmod3 ablation disrupts auditory function without compromising hair cell stereocilia development or MET competence
Haibo Du1, Xi Huang2, Sun Yixiao2
1Air Characteristic Medical Center Affiliated to PLA Air Force Military Medical University, Beijing, 100142, China; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Shandong University School of Life Sciences, Qingdao, Shandong, 266237, China.
Abstract:
F-actin cytoskeleton plays critical roles in hair cell. This study identifies LMOD3, an F-actin nucleator, as specifically expressed in outer hair cells (OHCs) of mice. Lmod3 knockout causes significant hearing loss (about 40 dB elevation in auditory brainstem response (ABR) thresholds, increased distortion product otoacoustic emission (DPOAE) thresholds), while leaving stereocilia morphology and mechanoelectrical transduction (MET) function intact. Phenotypic analyses hint that LMOD3 deficiency likely impairs OHC-based cochlear amplification. Our work establishes LMOD3 as essential for auditory function.
Related Concept Videos
Pleiotropy
Long-term Depression
Abnormal Proliferation
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Unrenewable Cells
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...

