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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Updated: Jun 29, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Low-Dose Radiotherapy for Primary Cutaneous Indolent B-Cell Lymphomas: a Multicenter Retrospective Study.

E Alì1, G Simontacchi2, M Levis3

  • 1Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia 42124, Italy.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|December 14, 2025
PubMed
Summary
This summary is machine-generated.

Low-dose radiotherapy (LDRT) shows promising efficacy for primary indolent cutaneous B-cell lymphomas (PCBCL), achieving high local control rates. This treatment is well-tolerated, with no severe toxicity observed in the study.

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Area of Science:

  • Oncology
  • Dermatology
  • Radiation Oncology

Background:

  • Primary indolent cutaneous B-cell lymphomas (PCBCL) represent about 20% of primary cutaneous lymphomas.
  • Radiotherapy (RT) is a recognized treatment for PCBCL.
  • Emerging evidence suggests low-dose RT schedules may be effective as initial therapy.

Purpose of the Study:

  • To assess the efficacy and safety of low-dose radiotherapy (LDRT) for PCBCL.
  • To evaluate local control and progression-free survival after LDRT.
  • To identify factors influencing treatment outcomes in PCBCL patients.

Main Methods:

  • Retrospective analysis of 75 patients with 137 PCBCL lesions treated between 2010 and 2023.
  • Lesions included Marginal Zone Lymphoma (77), Follicle Center Lymphoma (55), and other low-grade types.
  • LDRT was delivered via orthovoltage, electrons, or photons (3D-CRT).

Main Results:

  • High 48-month progression-free survival (42%) and local control rates (77%) were observed.
  • Larger lesions (>2.5 cm) and multifocal presentation correlated with poorer outcomes.
  • LDRT demonstrated a favorable safety profile with no grade 3+ toxicity events.

Conclusions:

  • LDRT is effective in managing PCBCL, offering excellent local control and a good safety profile.
  • Further prospective studies are needed to confirm these findings.
  • Optimization of LDRT treatment protocols for PCBCL is warranted.