BIOCHEMICAL ASSOCIATION BETWEEN CALCIUM HOMEOSTASIS AND SERUM URIC ACID LEVELS IN PATIENTS WITH HYPOTHYROIDISM: A...

The relationship between calcium, 1,25-dihydroxyvitamin D and serum uric acid levels in thyroid patients involves complex physiological mechanisms. This study aimed to evaluate the association of serum calcium and 25-hydroxyvitamin D with serum uric acid concentrations in individuals with hypothyroidism.

A Cross-sectional study conducted in Thumbay Hospital in Ajman UAE on 180 male and female with hypothyroidism and normal individuals, the study subjects divided into five age categories: 21-30, 31-40, 41-50, 51-60 and >60 years. The concentrations of calcium and uric acid in the samples measured by Beckman Coulter and DxI Analyzer, for the thyroid hormones and 25-hydroxyvitamin D (25-OH Vitamin D) tests used DxI Analyzer. The results analyzed by SPSS version 26, the mean and SD obtained, and "t" test independent, one-way ANOVA and Linear regression used for correlation and P value obtained to assess the significance of the results (p value of <0.05 was significant).

Among 180 participants, no significant difference age was seen between hypothyroid patients and controls (p=0.959). Hypothyroid patients showed markedly elevated TSH (p<0.001) and reduced FT4 (p = 0.001), calcium (p < 0.001), and vitamin D (p=0.012) levels, while uric acid increased significantly (p=0.015). Correlation analysis showed a weak negative association between uric acid and TSH (r=-0.082). Uric acid was higher in males (p=0.016), while calcium revealed significant differences across age groups (p=0.011), showed age-related alterations in calcium metabolism.

This study showed significant associations between calcium, 25-hydroxyvitamin D and serum uric acid levels in individuals with hypothyroidism. The negative correlations between uric acid and both calcium and 25-hydroxyvitamin D underscore the complex metabolic interactions characteristic of hypothyroidism.